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(86) conducted a randomized, double-blind, placebo-controlled trial over 8 weeks with 40 patients prone to episodic migraines, finding that omega-3 PUFAs supplementation increased anti-inflammatory cytokine IL-4 and decreased pro-inflammatory cytokine IFN- levels, suggesting a potential beneficial effect on inflammatory responses in migraine patients

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In contrast, under conditions of low cellular energy, an increased AMP/ATP ratio activates AMPK, which subsequently stimulates FAO through the activation of CPT1 [173]