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Later, Hornig and colleagues also suggested disturbed IL-1 signaling and autoimmunity-type patterns of immune activation while analyzing the cerebrospinal fluid in patients with atypical clinical characteristics (Hornig et al

Burns et al., Figure 1), takes place in the nervous tissue affected by ischemia (Amantea et al., 2016), its absence causes ATP depletion within only a few minutes, which is the result of no long-term energy stores in the brain (Doyle et al., + ) and Ca 2+ into the cell, accompanied by potassium ion (K + ) efflux

doi: 10.1038/s41598-023-40011-0 46 AlemannoFHoudayerEParmaASpinaADel FornoAScatoliniAet al

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Previous research revealed that NADPH oxidase 4 (NOX4), a source of cellular superoxide anions, induces FAO through carnitine palmitoyltransferase 1A (CPT1A) during NLR family pyrin domain-containing 3 (NLRP3) inflammasome activation and helps in the development of the inflammatory macrophage phenotype (76)