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The April 2024 paper and a comprehensive 2023 Pharmaceuticals review (PMC10224484) detail how peripheral BPC-157 administration produces corresponding central nervous system effects through multiple mechanisms

PMID: 33435798 Nat Protoc2023 Apr;18(4):1028-1055

With regard to the long-term use of iron chelators in patients with chronic diseases, these patients may experience specific side effects, such as rash, nausea and dizziness, diarrhea, vomiting, hearing and vision loss, abdominal pain, and increasing risk of infection (Mobarra et al., 2016

Additionally, tyrosines play an important role in aSyn-vesicle binding while nitration impairs this interaction (making the charge more negative at the N-terminal domain, or causing a conformational change when the C-terminal domain is nitrated) thereby increasing the amount of aSyn in a random coil or beta-sheet conformation and thus shifting equilibrium toward oligomer formation 105,106,109

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