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Current therapies include ERT to compensate for the missing or defective enzyme, and substrate reduction therapy to reduce the accumulation of toxic substances by limiting their production

There is a regular feedback of errors from the DMC to the study sites

These factors promote the activation of fibroblasts and the excessive production of ECM components

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Targeting thioredoxin reductase by eupalinilide B promotes apoptosis of colorectal cancer cells in vitro and in vivo