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-Tocopherol (30 mg/kg, i.p.) has shown beneficial effects in experimental renal ischemia, including reduction in tubular damage scores and cast formation, decreased blood urea nitrogen (BUN) and creatinine elevations, protection against oxidative DNA damage in renal tubular cells, and preservation of glomerular filtration capacity [53]

246 RottoliP.MagiB.CiantiR.BargagliE.VagagginiC.NikiforakisN.et al (2005)

Furthermore, melatonin restores H3K18la and STEAP3 expression both in vitro and vivo, thereby suppressing ferroptosis and reducing oxidative stress