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Schalock 2014

341,342 The increased expression of NAMPT in aging human SMCs prolonged lifespan via delaying senescence and enhancing resistance to oxidative stress

Scimemi, A., Tian, H

10.1016/0006-2952(95)00019-V 9

This nitrosylation reduced Ero1s oxidative enzyme activity, an essential enzyme for oxidative protein folding in the ER, leading to ER reductive stress and subsequent cellular senescence [59]