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The beneficial effect of YPS1 gene disruption on intact HSA-pFSH production and degradation was associated with upregulation of the MAPK signaling pathway and maintaining redox homeostasis

2.7 Molecular dynamics simulation Molecular dynamics simulations were conducted on the top three complexes with the highest molecular docking scores using the Amber18 software package

Exogenous supplementation with this bacterium reduced urinary protein, blood urea nitrogen, and creatinine levels in DKD mice, decreased plasma levels of uremic toxins including TMAO, p-cresyl sulfate, and indoxyl sulfate, and protected intestinal mucosal barrier integrity through upregulation of MUC2, occludin, and ZO-1 protein expression [Animal model evidence only]

Mazalli MR, Maldonado RR, Aguiar-Oliveira E

Human GH receptor-IGF-1 receptor interaction: implications for GH signaling