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Microcosmically, CPT1A and CPT1B are both located in the outer membrane of the mitochondria, whereas CPT1C is localized to both the endoplasmic reticulum and mitochondria (Dai et al., 2007

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Rennard SI, Vestbo J

On the other hand, TMAO decreases expression of two key enzymes, CYP7A1 and CYP27A1, essential for bile acid biosynthesis and multiple bile acid transporters (OATP1, OATP4, MRP2 and NTCP) in the liver, which decreases bile acid pool, resulting in decreased reverse cholesterol efflux (Koeth et al., 2013)