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L.SabinR.FrahlerK.HarrisC.PetrikoB.et al (2011)

In 2 compartment models, where the drug equilibrates between blood and (for example) adipose tissue, during elimination there is a sharp initial fall in blood levels followed by a gradual subsequent fall

[DOI] [PMC free article] [PubMed] [Google Scholar] 123.Stockli J, Zadoorian A, Cooke KC, Deshpande V, Yau B, Herrmann G, et al

Strategies for Overcoming Developmental Challenges Strategies for overcoming developmental challenges in order to bring these promising treatments into clinical practice include: Personalized Approaches: One way to address the challenges of clinical translation is through personalized medicine

These local reactions typically resolve quickly and diminish with continued use as technique improves