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Under oxidative stress conditions, BH 4 is swiftly oxidized to BH 2 by superoxide anions, particularly peroxynitrite generated by the scavenging of NO by O 2 , and BH 2 can subsequently be regenerated into BH 4 through the dihydrofolate reductase (DHFR) recovery pathway

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They analyzed dozens of experimental and clinical studies, looking at both natural molecules (like NAC, milk thistle, and whey protein) and pharmaceutical approaches (like dimethyl fumarate or bardoxolone)

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Rainis T, Maor I, Lanir A, Shnizer S, Lavy A (2007) Enhanced oxidative stress and leucocyte activation in neoplastic tissues of the colon