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Description

In addition to mitochondrial ROS from Complexes I, II, and III, enzymes, such as the -ketoglutarate dehydrogenase (KGDHC) and pyruvate dehydrogenase (PDC) complexes, involved in mitochondrial metabolism also produce ROS through forward electron transfer, and both act as important sources of ROS in the mitochondria (8587) ( Figure 1 )