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For the tested inhibitors, we used doses in the known IC50 ranges, evidencing minimal effects on cell viability

Abstract This study evaluated the effect of thymoquinone (TQ) on the hepatorenal system of rats intoxicated with mercury (HgCl 2 )

In addition, SIRT1 deacetylates FOXOs and stimulates FOXO-dependent antioxidant [such as catalase (CAT), manganese superoxide dismutase (MnSOD) and thioredoxin] expression to eliminate ROS in endothelial cells, and prevent endothelial dysfunction [78-80]