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When selecting medications, we take into account whether patients are older or have other health conditions, and we prescribe them in a safe combination for the shortest possible duration to avoid medication overload

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To evaluate trophoblast-related functions including invasion and cellular response, TNF- was given to HTR8 cells to induce inflammatory PE model in vitro, and qPCR results showed that TNF- treated group had significantly increased HIF-1 and sFlt-1expressions, while LBNP-PC@M treatment effectively downregulated these two factors (Fig