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Its unique mechanism has made it one of the most extensively studied peptides for exploring the biological processes associated with cellular aging and long-term tissue maintenance

For a long time, calcitriol or alfacalcidol was the preferred therapy in uremic patients with high to very high plasma intact PTH values and normal to moderately elevated plasma calcium levels, when plasma phosphate did not exceed recommended levels, namely 1.5 mmol/L for CKD stages 3-4 and 1.8 mmol/L for CKD stage 5, according to the K/DOQI guidelines of 2003 (275)

These metabolites, particularly bacterial metabolites, play an important role in microbiotahost interactions and influence the immune system and the BM microenvironment

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While ROS production is a natural response to environmental changes, prolonged exposure to elevated ROS levels or oxidative stress facilitates the occurrence and exacerbation of skin diseases (37)