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This enhancement synergistically improves the osteogenic capability of BMSCs and promotes angiogenesis, which are critical for successful osseointegration that requires efficient bone regeneration involving BMSC recruitment, differentiation, and new vessel formation

Even if the solution appears clear after thawing, the tertiary structure has been irreversibly altered

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For quantitative evaluations, images were collected with a BX51 Olympus microscope

Nonetheless, these promising transplanted sites are relatively hard for surgical operation and post-transplantation monitoring