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Zhang S, Li X, Zhang F, Yang P, Gao X, Song Q (2006) Preparation of yuanhuacine and relative daphne diterpene esters from Daphne genkwa and structureactivity relationship of potent inhibitory activity against DNA topoisomerase I

Proposed Mechanisms Preventing GABA receptor downregulation Counteracting compensatory NMDA glutamate receptor sensitization Stabilizing benzodiazepine receptor configuration (preventing shift to inverse agonist state) Upregulating GABAergic neurotransmission through pathways distinct from benzodiazepine action itself This tolerance prevention has profound clinical implications