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While oxygen is necessary for life, it can also be a dangerous unregulated free radical

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10.1016/j.canep.2023.102451 [DOI] [PubMed] [Google Scholar] 47.Talapko J, Metrovi T, Dmitrovi B, Juzbai M, Matijevi T, Beki S, et al

Examination of bloodbrain barrier (BBB) integrity in a mouse brain tumor model

It is rapidly converted to acetate by aldehyde dehydrogenase (ALDH) within the mitochondria and cytosol ( (2) The Microsomal Ethanol Oxidizing System (MEOS): This pathway involves the metabolism of ethanol to acetaldehyde in the mitochondria, converting NADPH and O 2 into oxidized nicotinamide adenine dinucleotide phosphate (NADP+) and H 2 O, while simultaneously producing ROS ( 2 O 2 ) and hydroxyl radicals (OH) ( (3) Other Oxidative Pathways: These include reduced nicotinamide adenine dinucleotide phosphate (NADPH) oxidase-catalase (CAT) and xanthine oxidase-catalase (XO-CAT) systems (Zima et al., 2001)