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Oxidative DNA adducts such as 8-oxoG are not only lesions but also contextual signals that recruit base-excision machinery (e.g., OGG1) and remodel local chromatin, thereby coupling genome surveillance to transcriptional tuning

N-Acetyl-L-Cysteine (NAC) is an amino acid that is a precursor to glutathione, the bodys most powerful antioxidant, which helps support optimal liver detoxification, lung health, antioxidant status, and muscle recovery

This network underscores the essential role of bidirectional microbiotametaboliteimmune crosstalk in SLE and provides a rationale for targeted interventions (such as FMT, probiotics, metabolite supplementation, etc.), aiming to restore immune homeostasis through multiple pathways (Fig

These plasmids were used to transform Escherichia coli BL21(DE3)