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By tipping the scales in favor of anti-apoptotic signals, CsA helps to mitigate mitochondrial apoptosis, a process that contributes to cell death and tissue damage in DE conditions

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"The effect of B-vitamins on biochemical bone turnover markers and bone mineral density in osteoporotic patients: a 1-year double blind placebo controlled trial"

21,26 The biomechanical balance of loading and unloading the spinal column contributes significantly to the IVD metabolism, and alterations in this balance lead to unfavorable changes in the cellular matrix, resulting in disc degeneration