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In another study, conditional pancreatic Ngf overexpression in KC (LSL-Kras +/LSL-G12D

HbS polymers rapidly elongate to form fibrous strands, inducing erythrocyte sickling [12]

This metabolic adaptation enables differentiating osteoblasts to rapidly generate ATP and essential metabolic intermediates required for bone matrix production and mineralization (Esen and Long 2014)