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Aggregates of alpha-synuclein (syn) phosphorylated at serine 129 (PSER129) are hallmarks of synucleinopathies, which, for PD/DLB, are found predominantly in neurons, whereas in MSA, aggregates are primarily found in oligodendroglia

Building on this mechanistic foundation, this article critically assesses the evolving therapeutic landscape

Many thanks to Irvin Jasper Barcelon and his wife Rizza Bautista, Judith Bautista, Maria-Cecilia Marasigan and all the staff at Chateau Westmount

Melatonin is the endogenous pineal hormone that signals circadian timing and is the standard research-supported sleep-onset compound

& Ferencik, M