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Generally speaking, suppositories are considered to be more effective than oral supplements but why

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A small, randomized, controlled, crossover trial involved 18 participants, average age 51 years, with obesity and prediabetes who underwent a 10-week intervention with cinnamon (4 grams per day) or placebo

doi: 10.1128/mBio.02183-16 264 FuMSCoelhoCDe Leon-RodriguezCMRossiDCPCamachoEJungEHet al

Evidence suggests that GPR81 is an anti-inflammatory pathway that inhibits NLRP3 inflammasome release by activating the intracellular adaptor protein, -arrestin 2 (ARRB2), and attenuating NF-B activity ( Figure 3 ) (159)