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Similarly, the gut microbiota member Fusobacterium nucleatum and its product succinic acid confer resistance to anti-PD-1 mAb by inhibiting the cGAS-interferon- pathway, thereby impairing CD8+ T cell-mediated anti-tumor immunity in the CRC

Several of these commenters noted that, because of the uncertainty ( surrounding the timeline for sunsetting the Medicare CQM collection type, Shared Savings Program ACOs and EHR vendors are reluctant to invest time and resources in an option that may be eliminated with little to no warning

doi: 10.1038/nature13564

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