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iPSC-derived microglia carrying the TREM2 R47H/+ mutation are proinflammatory and promote synapse loss

As expected, most of the irradiated cells, except NCI-H1975 and Calu-6, showed an increase in residual DNA damage 24 h post-RT, which was not further enhanced by the combination treatment (Supplementary Fig

Additionally, the metabolism of arginine influences macrophage polarisation, with M1 macrophages producing toxic nitric oxide (NO) and M2 macrophages contributing to tissue repair and healing through the arginase pathway (60, 61)