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However, NSAIDs may lead to gastrointestinal bleeding and other adverse effects, while DMARDs can cause immune suppression, increasing the risk of infections (12, 16, 17)

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3.3.4 Immune microenvironment remodeling and immunotherapy resistance Resistance to targeted therapy primarily involves cell-intrinsic signaling adaptation within tumor cells, whereas resistance to immunotherapy entails more complex intercellular crosstalk

10.1016/j.jep.2011.02.019 35 ColovicM