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Ouabain, a natural compound belonging to the cardiac glycosides family, reduces cell survival through apoptotic pathway in human senescent cells induced by genotoxic stress (Etoposide, Doxorubicin and Palbociclib), OIS, or replicative exhaustion

These changes only to a small extent include the genes controlled by Nrf2

The implanted mice were still observed after the surgical removal of primary xenografts to evaluate whether the xenografts preserved the recurrence that characterizes the corresponding patient glioma

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[PubMed] [Google Scholar] 65.Kats R, Collette T, Metz CN, Akoum A