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[74] Regulation of pyruvate kinase activity Another key control point for carbon flux through glycolysis and gluconeogenesis is the substrate cycle between phosphoenolpyruvate and pyruvate, catalyzed by pyruvate kinase in glycolysis and by the combined action of pyruvate carboxylase and phosphoenolpyruvate carboxykinase (EC 4.1.1.32) in gluconeogenesis