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Elevated cytokine levels might suppress telomerase activity, thereby limiting the enzymes ability to counteract telomere shortening and leading to cellular senescence ( 2.3.3 Interconnected dynamics of cellular aging: the telomere-mitochondrial axis Telomere shortening can disrupt normal cellular function and is implicated in the increased production of ROS, which further contribute to mitochondrial dysfunction and cell aging (Sahin and DePinho, 2010)

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While the treatment has gained popularity in clinics and wellness centers, many skin specialists point out a gap between its widespread use and the available scientific evidence

Therefore the use of IgM test would allow for direct screening of the sample and serve as a diagnostic tool for establishing active or recent infection (Alem et al., 2002, Elseweidy et al 2010)