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Interestingly, Lai et al

2017;1862(10 Pt A):1068-1078

The HIF-1 activation triggers a proangiogenic host cell response with increased levels of vascular endothelial growth factor (VEGF) and up-regulation of genes for the GLUT-3 and glycolytic enzymes (Kempf et al., 2005) thereby inhibiting apoptosis