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Glutathione not only has a role in the skins melanin formation, it can also interrupt the enzyme that causes melanin overproduction

Under physiological conditions, more than 98% of the total GSH pool exists in the reduced form, thereby shaping cellular redox potential and influencing proliferation, differentiation, and cell death 5 .Although the GSH/GSSG ratio has long been regarded as an indicator of cellular redox status, recent live-cell studies using genetically encoded redox sensors indicate that increases in GSSG are typically transient and compartmentalized rather than sustained intracellular accumulations 6,7

Since the balance is maintained by the presence of adequate amounts of antioxidants, measuring levels of the antioxidants, individually or as total antioxidant capacity (TAC), has also been examined [15, 18, 42, 43]

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The therapeutic effects of human mesenchymal stem cells primed with sphingosine-1 phosphate on pulmonary artery hypertension