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we observed a strong growth defect and massive cell death in the LHON-edited cells, but not in the SILENT-edited cells (population doublings per day: LHON 0.64 0.11, SILENT 0.52 0.07

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AST-fed db/db mice also showed reduced numbers of NF-B + and PCNA + cells and decreased gene expressions of IL-6, IL-1, F4/80, chemokine (C-C motif) ligand 2 (CCL2), and chemokine (C-X-C motif) ligand 2 (CXCL2) in the colon

Microbial metabolites such as SCFAs and tryptophan catabolites can influence brain function directly or via modulation of systemic inflammation

8.5 Cell-free strategies In recent years, researchers have discovered that extracellular vesicles (EVs) secreted by stem cells, such as exosomes and microvesicles, possess immunomodulatory functions similar to stem cells (Yu et al., 2014)