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October 21, 2022

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A fundamental challenge lies in the ubiquitous nature of mitochondrial processes across tissues, creating inherent risks for off-target effects when systemically targeting pathways such as fission, fusion, or metabolism

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2, MTHFR catalyzes the physiologically irreversible reduction of 5,10-methylene THF to 5-methyltetrahydrofolate (5-methyl THF), and plays a critical role in one-carbon metabolism for the reaction of producing methyl groups to participate in epigenetic regulation 18