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VEGF-A, vascular endothelial growth factor-A

It promotes healing by upregulating growth factors, stimulating angiogenesis (new blood vessel formation), and enhancing collagen synthesis

33 This process is further enhanced by SQSTM1 that increases NFE2L2 protein stability through the inactivation of kelch-like ECH-associated protein 1 (KEAP1), an adapter protein of the Cullin3-based ubiquitin E3 ligase complex responsible for NFE2L2 ubiquitination

These results demonstrate that FGF-2 contributes to anti-VEGF drug resistance in a breast cancer model

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