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Ferris et al., 2017

Capsaicin is a potent activator of TRPV1, a thermoreceptor that senses temperatures greater than 42C [19]

Xanthine oxidase (XO), which participates in purine metabolism, is another key enzymatic source of ROS, producing both superoxide and HO during the conversion of hypoxanthine to xanthine and xanthine to uric acid 50

Comet Assay in vivo ECVAM has been involved in the Validation Management Team for the validation of the comet assay in vivo, which was coordinated by the Japanese Centre for the Validation of Alternative Methods (JaCVAM) (Uno et al., 2015)