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Magnoliae officinalis cortex (Houpo)s benefit was for lung disease, and intestinal function [20]

AMPK activation during energy deficiency can both inhibit ferroptosis, through phosphorylation of ACACA/ACC (acetyl-CoA carboxylase alpha) in MEFs (mouse embryonic fibroblasts) and human renal adenocarcinoma cells [68], and promote ferroptosis, by targeting BECN1 (beclin1)-mediated system xc - inhibition in human colorectal cancer cells [25] or regulating pyrimidinosome assembly in human cervical cancer cells [69]

doi:10.4088/JCP.19m13207 2

Importantly, PDGF signalling bypasses IRS and thus provides a tool to test the role of IRS in insulin resistance

Acknowledgement Figure 1A is a courtesy of S