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Gouaze V, Mirault ME, Carpentier S, Salvayre R, Levade T, Andrieu-Abadie N

Complex V catalyzes the final step of oxidative phosphorylation by converting adenosine diphosphate to ATP

These approvals bolster the importance of glutamate in depression and represent an exciting breakthrough in contemporary psychiatry, providing new avenues of treatment for patients as first-line therapy or with either poor response or unacceptable side effects to monoaminergic antidepressants