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The activation of protease-activated receptor 2 (PAR2) triggers an inflammatory response by phosphorylating Nuclear factor kappa-light-chain enhancer of activated B cells (NF-B) and Forkhead box O 6 (FoxO6) through the Protein kinase B (Akt) pathway, which could serve as a crucial mechanism for ROS-induced inflammation (51)

Clinical trial data shows sustained efficacy through 48 weeks with minimal plateau concerns

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all of the above are GONE

Fine lines and wrinkles, especially around high-movement areas like the eyes, mouth, and forehead