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Alpha-1 antitrypsin deficiency affects approximately 1 in 2,0006,000 individuals globally, with an estimated 3.4 million people harboring severe deficiency alleles and over 116 million carriers worldwide [20, 21]

doi: 10.1016/j.ajog.2008.07.048 Summary Keywords preeclampsia, nutrient metabolism, pathogenesis, carbohydrate, lipid, amino acids Citation Li S, Zhu J, Zhao Y, An P, Zhao H and Xiong Y (2025) Metabolic disorder of nutrientsan emerging field in the pathogenesis of preeclampsia

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IR and an excessive influx of FFAs drive an overload of fatty acid -oxidation, increasing ROS and causing a loss of mitochondrial membrane potential (m)