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GIP receptor activation enhances insulin secretion, improves fat metabolism, and may contribute to central nervous system effects on appetite that go beyond what GLP-1 alone can achieve

And how do you know if something more serious is going on

The abnormal cholesterol profile in patients with preclinical RA and early RA is typical of metabolic syndrome: normal or mildly elevated total cholesterol, LDL cholesterol and triglycerides, associated with decreased HDL cholesterol levels (122, 123)

Folate Health Professional Fact Sheet.

Five supplements have the strongest evidence base for you at this age: folic acid, vitamin D, omega-3 (EPA/DHA), CoQ10 (preferably ubiquinol), and a high-quality prenatal multivitamin