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Polyphenols as antitumor agents targeting key players in cancer-driving signaling pathways

Sharon G, Sampson TR, Geschwind DH, Mazmanian SK

doi: 10.3390/ijms23169340, 23

Increased sensitivity to alcohol, medications, or environmental exposures

Moreover, achieving signaling bias through allosteric modulation could enhance the safety of M1-mAChR drugs, making it a key consideration in the development of M1-mAChR allosteric ligands