glutathione and fe Functionalized Fe-Doped Carbon Dots Exhibiting Dual Consumption to Amplify Ferroptosis for Enhanced Cancer Therapy Antioxidants are an important part of a healthy diet but are easily destroyed in digestion. Glutathione/Glutaredoxin in Cellular Redox Homeostasis

bulgaricus , a folate consumer, usually contains 2-fold higher amounts of folate compared to the original milk

Iron overload As a common trace element, iron is distributed in the liver, spleen and bone marrow of the human body, which is closely related to the hematopoietic function of body and is necessary to maintain the normal life activities of human [22, 23]

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On the other hand, inhibition of GSH synthesis with BSO, independently of the cysteine pool, has been repeatedly described to induce ferroptosis ( via depletion of mitochondrial GSH pool leading to the release of cytochrome c, when combined with chemotherapy in breast cancer and leukemia, respectively (71, 72)

Storage Guidelines: Store refrigerated at 28C Protect from light exposure Minimize moisture contact Avoid repeated freeze-thaw cycles Follow appropriate laboratory handling protocols The compound is supplied dry and is not pre-reconstituted