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During the preparation of this work, the author(s) used ChatGPT to correct the grammar, language and used Google Gemini to create Figure 1

Clarke C, Gallagher C, Kelly RM, Henry M, Meleady P, Frye CC, Osborne MD, Brady CP, Barron N, Clynes M (2019) Transcriptomic analysis of IgG4 Fc-fusion protein degradation in a panel of clonally-derived CHO cell lines using RNASeq

doi: 10.1038/nsmb922

Specifically, as proposed in a hypothetical model shown in Figure 7(b), if a protein or a small molecule target could be designed under diabetic conditions to reduce metabolic pressure on complex I, that is, relaying excess electrons from NADH to CoQ, such a target could serve as a potential therapeutic approach by restoring NADH/NAD + redox balance in the absence of enhanced proton pumping and ROS production