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GHK-Cu signals fibroblasts (the skin's collagen-producing cells) to upregulate the production of types I, II, and III collagen, as well as elastin, glycosaminoglycans, and decorin

10.1016/j.jad.2023.07.040 130 LeiX.XuZ.HuangL.HuangY.TuS.XuL.et al (2024)

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For example, GA can trigger mitochondrial apoptotic signals: it upregulates Bax, downregulates Bcl-2, and activates caspase-9 and 3, leading to programmed cell death in various carcinoma cells (148)

Glutamate-cysteine ligase catalytic and modulator subunits as well as GSH synthetase are the three NRF2 targets involved in the GSH synthesis (242)