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3KO) by treating two paired HR-NB PDX models derived from the same patient (Table S1): LU-NB PDX3 is a primary treatment-responsive model with an overall ADR phenotype, and LU-NB PDX3-R is a chemoresistant relapse model with a primarily MES phenotype 12

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(52, 53) found that green tea had an antihypertensive effect on hypertension induced by a high salt diet in aged male rats, and its main mechanism of action included inhibiting the activity of the renin-angiotensin II-aldosterone system, altering the expression of sodium-potassium pumps in heart, kidney and aortic tissues and increasing the synthesis of nitric oxide in endothelial cells

J Neurochem 2010

"Were sort of at a point now where we have to make decisions based on imperfect evidence."