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We find that neurons overexpressing WT ArfGAP1 reveal a marked reduction in neurite length relative to control (empty vector) neurons, whereas unexpectedly, single ArfGAP1 phospho-null mutants (S284A, T291A or T292A) also markedly reduce neurite length to levels similar to WT ArfGAP1 ( Fig

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The reality is more nuanced: The critical difference is clinical validation depth

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Brit J Clin Pharmacol

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Simultaneously, nicotinamide is consumed reducing the substrate available for the salvage pathway to regenerate NAD+

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