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These pathways involve integrins, which are transmembrane proteins that connect the ECM to the cytoskeleton

Progesterone enhances the activity of GABA, a calming neurotransmitter that promotes relaxation and sleepiness

All animal experiments were approved by the Institutional Ethical Committee and Research Advisory Committee of Mashhad University of Medical Sciences guidelines (Ethical number: 960881) and all animal experiments and methods were carried out in accordance with the relevant guidelines and regulations approved by the ethical committee and ARRIVE guidelines 60

In cerebral ischemia models, schisandrin B enhances VEGF expression and supports neovascular remodeling