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The absence of large-scale clinical trials means that its efficacy and safety in humans have not been sufficiently established

Watch for These Red Flags Make an appointment with a healthcare provider for an evaluation if you experience: unintentional weight changes (weight gain or weight loss) persistent insomnia heart palpitations fainting In addition, if you experience new or worsening anxiety, depression, or signs of disordered eating that are getting in the way of your quality of life and ability to function, talk with your healthcare professional

van Essen et al., 2009)

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