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Discovery of a novel NAMPT inhibitor that selectively targets NAPRT-deficient EMT-subtype cancer cells and alleviates chemotherapy-induced peripheral neuropathy

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Current use is limited to research purposes under physician supervision

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Extracellular NAD + can enter cells via pore-forming channel connexin 43 (Cx43), a bi-directional NAD + transporter allowing exogenous NAD + transportation into the cell, and transportation out for utilization of NAD + by CD38 64