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This temporary response happens because GLP-1 medications slow stomach emptying and signal fullness to your brain, creating sensations that fade as your body adjusts over several weeks

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Metformin, a first-line diabetes medication, interferes with B12 absorption in the terminal ileum through mechanisms involving calcium-dependent membrane action and bacterial overgrowth

doi: 10.1681/ASN.2019111206 23

The concurrent use of both substances can complicate drug test outcomes by increasing the likelihood of testing positive for THC