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The MDCT technique uses a clinical-grade rotary tattoo machine operated by a dermatologist, with compounded prescription medications (dutasteride requires a prescription) and scalp anaesthesia

PSEN1 deletion or loss-of-function mutations causing AD reduce V0a1 delivery to lysosomes, lysosomal V0a1 content, v-ATPase activity and lysosomal acidification 94,108,117120,122125

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Antioxid Redox Signal 13(9):13591373 Eskes R, Antonsson B, Osen-Sand A, Montessuit S, Richter C, Sadoul R, Mazzei G, Nichols A, Martinou JC (1998) Bax-induced cytochrome C release from mitochondria is independent of the permeability transition pore but highly dependent on Mg2+ ions